Nolan Arenado hit his NL-leading 38th home run and Colorado center fielder Charlie Blackmon made a leaping catch Thursday to help preserve the Rockies' 4-3 win over the San Diego Padres.
Blackmon reached above the wall to rob pinch hitter Brett Wallace of a tying home run with one out.
Carlos Gonzalez hit his 37th homer for the Rockies and Daniel Descalso hit a tiebreaking shot leading off the eighth. Corey Dickerson also connected for Colorado.
Descalso homered off Joaquin Benoit (6-5), who hadn't pitched since Saturday because of back spasms.
Arenado has homered in eight of his 11 games in September. He leads the league with 108 RBIs.
Justin Miller (1-0) struck out the side in the seventh, and fanned all seven batters he faced in the series. John Axford closed for his 21st save in 26 chances.
Matt Kemp homered for San Diego and has reached base in a career-high 30 consecutive games.