So what happens with all the money they make? It all goes to Children's Hospital.
"We give to the hospital. Every month we give them a check that was our net income, after expenses, what we made that month," longtime volunteer Lorna Cheldelin told Denver7.
The shop was started back when Children's Hospital was in downtown Denver. Listen to some of the stories that pass through the shop, and you'll hear of a little corner room in the back warehouse of the old hospital, or of wine and cheese parties to promote the shop among the doctors and nurses.
"We just stumbled along and learned throughout the years," volunteer Charla Rudolph said.
They learned, and grew over the years.
"Our first year we netted $13,333. It went to $18,000, $34,000, and it grew and grew," Cheldelin said.
Nine miles down Colfax, as soon as you walk into the hospital, you will see the impact. Donations from La Cache bought the patient check-in area, and now funds the research unit studying allergy diseases in kids.
"La Cache has had a tremendous impact. We could not afford to send our researchers to meetings, to have our research assistants do the cutting edge research that they do here at Children's Hospital Colorado," Dr Glenn Furuta, who runs that unit, said with a smile.
And you just can't put a price tag on that.
"Somebody once asked me if I'd do this for money," volunteer Marilyn Kessler said. "I wouldn't. There's not enough."